RAF Typhoon jets have operated alongside French aircraft in a coordinated attack on an subterranean weapons facility in Syria employed by the IS group, according to the UK's MoD.
The site, located using reconnaissance, was believed to be containing munitions and bombs, the release indicated, and was positioned in mountainous terrain just north of Palmyra in the heart of Syria.
"Our aircraft utilized Paveway IV guided bombs to target a several approach shafts providing entry to the depot... initial indications suggest the strike was effective," officials stated.
There was no evidence of any civilian casualties in the operation on Saturday evening and every plane involved returned safely, the ministry further stated.
The Typhoon fighters were supported by a Voyager refuelling tanker.
IS - also known as ISIS - established extremist governance over significant areas in Syria and Iraq until 2019.
"This action underscores British leadership, and commitment to operate in unison with allied nations, to eradicate any resurgence of Daesh and their dangerous and violent ideologies in the Middle East," UK Defence Secretary the Defence Secretary remarked.
British military aircraft have performed patrols over Syria to "prevent any attempted resurgence" of Islamic State after its defeat at the battle of Baghuz in 2019, the ministry said.
"I want to thank every member of the UK armed forces who took part in this mission for their expertise and their valour," Healey added. "They were part of a great many UK service members on duty over the holidays. This action, to eliminate dangerous terrorists who endanger our safety, shows how UK forces are ready to step up, throughout the year, keeping Britain secure at home and strong abroad."
During December, the US military carried out what it termed a "large-scale strike" targeting Daesh sites in Syria, subsequent to an ambush resulted in the deaths of two US troops and a civilian linguist in Palmyra.
The U.N. estimates Islamic State still has an estimated 5,000 to 7,000 fighters in Iraq and Syria.